Read all: I had some initial, temporary, dramatic results very shortly after starting Ampyra (brand name of 4-AP). Unfortunately, those dramatic results have tapered down immensely, but it was wonderful while it lasted! Initially, I had huge improvements in balance, leg strength, and feeling in legs/feet. I continue to have cognitive benefits from the drug, though that is not one of their claims. When I briefly stopped taking the drug a few months ago, I noticed much more brain fog. It improved immensely when I restarted Ampyra.