Infertility Treatments May Significantly Increase Multiple Sclerosis Activity

Infertility Treatments May Significantly Increase Multiple Sclerosis Activity

Estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism and estrogen replacement therapy acts to reduce the elevated levels of these hormones seen in postmenopausal women.

6 pensamientos en “Infertility Treatments May Significantly Increase Multiple Sclerosis Activity”

    1. Almost every study I know about it, they say the opposite of what represents the study, so I posted on the blog, and that caught my attention. The related study, most significant published Annal of Neurology, said that the probable cause is the increase of macrophages and astrocytes mediated by T lymphocytes +. In MS patients reduce relapses (experiment in mice), and also, decrease brain lesions in patients with intermittent relapses and in progressive MS (study of 12 patients).
      Thank you very much for answering.

      Jesus Santiago.

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    1. Thank you very much for writing. I hope the blog will be useful for everyone. Try to be diverse news that matters to everyone. Thanks for the encouragement they are giving me. I never thought I could help so many people.
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      Jesus Santiago.

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